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. 2019 Oct 9;105(7):1835–1844. doi: 10.3324/haematol.2018.212589

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The iron-restrictive effect of minihepcidin improved ineffective erythropoiesis in Hbb^th1/th2-BMC mice. Minihepcidin improved (A) red blood cell (RBC) morphology and (B) RBC lifespan [statistics are determined comparing animals treated with vehicle (V) vs. high-dose minihepcidin (MH_H)]. (C) Minihepcidin also improved erythropoiesis in the bone marrow (BM) and spleen of Hbb^th1/th2-BMC mice. (D, E) Flow activated cell sorting analysis of the percentage of BM (D) and splenic (E) erythroid cells using CD44⁺ and Ter119⁺ cells (n=4-5 animals per group). Results are presented as means ± standard deviation: ****P≤0.001, **P≤0.01, *P≤0.05.