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. 2019 Oct 9;105(7):1835–1844. doi: 10.3324/haematol.2018.212589

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Improved iron parameters and splenomegaly in Hbb^th1/th2-BMC mice treated with minihepcidin and blood transfusion. (A) Hepcidin (HAMP) levels increased in the group given blood transfusions (Bl.Tr.) with or without high-dose minihepcidin (MH-H). (B) Transferrin saturation levels were not statistically different in treated or untreated animals. (C) Serum iron levels were decreased in the animals given blood transfusions compared to animals treated with vehicle (V) alone and were similar to those in animals treated with MH-H. (D) Liver iron content was decreased in animals given blood transfusions (with or without MH_H) when compared to animals treated with vehicle and similar to those treated with MH_H alone. (E, F) Total iron content in the heart (E) and spleen (F) was decreased. (G) Spleen weight was almost normalized in MH_H- treated mice, transfused or not. Bars represent the standard deviation. ****P≤0.001, ***P≤0.005, **P≤0.01; *P≤0.05.