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. 2019 Sep 26;105(7):1895–1906. doi: 10.3324/haematol.2019.230961

Figure 2.

Figure 2

Morphological and immunophenotypic features of CD8+ indolent T-cell lymphoproliferative disorders of the gastrointestinal tract. (A) An ileal biopsy (case 8) shows a dense mucosal lymphocytic infiltrate expanding the lamina propria and widening the villi; no villous atrophy is present but the crypts are hyperplastic. (B) Small clusters of lymphocytes are seen within the villus epithelium along the lateral edges. There is no increase in intraepithelial lymphocytes. (C) The lymphocytes are small and have round or oval nuclei, condensed chromatin, indistinct nucleoli, and scant to moderate clear or pale pink cytoplasm. The lymphocytes express (D) CD8 and (E) CD3. Most of the cells express the cytotoxic marker (F) TIA1 and (G) granzyme B is expressed by a subset. (H) The lymphocytes are CD103+ and a subset expresses (I) CD56. (J) The Ki-67 proliferation index is low (<5%). The majority of cells express (K) GATA3, but 60% also show (L) T-bet expression.