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. 2020 May 25;11(7):1963–1971. doi: 10.1111/1759-7714.13489

Figure 3.

Figure 3

HEIH served as a molecular sponge of miR‐4458 in esophageal squamous cell carcinoma (ESCC). (a) There were binding sites between HEIH and miR‐4458. (b) The luciferase activity of HEIH –WT and HEIH‐MUT (Inline graphic miR‐NC and Inline graphic miR‐4458). (c) The expression of miR‐4458 in EC109 cells (Inline graphic NC, Inline graphic HEIH vector, and Inline graphic HEIHvector+miR‐4458 mimics). (d) The expression of miR‐4458 in ESCC tissues (Inline graphic si‐NC, Inline graphic si‐HEIH, and Inline graphic si‐HEIH+miR‐4458 inhibitor). (e) The expression of miR‐4458 in ESCC cell lines. (f) There was a negative correlation between HEIH and miR‐4458. **P < 0.01.