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. 2020 May 25;11(7):1963–1971. doi: 10.1111/1759-7714.13489

Figure 5.

Figure 5

HEIH modulated esophageal squamous cell carcinoma (ESCC) cell progression via regulating miR‐4458/PBX3. (a) The expression of PBX3 (Inline graphic si‐NC, Inline graphic si‐HEIH, Inline graphic miR‐4458 inhibitor, and Inline graphic si‐HEIH+miR‐4458 inhibitor). (b) Cell proliferation was inhibited by si‐PBX3, while miR‐4458 or HEIH vector destroyed the inhibition (Inline graphic si‐NC, Inline graphic si‐HEIH, Inline graphic miR‐4458 inhibitor, and Inline graphic si‐HEIH+miR‐4458 inhibitor). (c) Cell invasion was suppressed by PBX3 silencing, while increased by miR‐4458 or HEIH vector (magnification: 20×) (Inline graphic si‐NC, Inline graphic si‐HEIH, Inline graphic miR‐4458 inhibitor, and Inline graphic si‐HEIH+miR‐4458 inhibitor). (d) PBX3 was negatively correlated with miR‐4458. (e) PBX3 was positively correlated with HEIH. **P < 0.01.