Table 1.
List of anticancer drugs with reported resistance mechanisms mediated by exosomes.
| Drug | Resistance factor | Expression change in resistant cells | Target | Cancer | Reference | |
|---|---|---|---|---|---|---|
| 1. | Oxaliplatin | hsa_circ_0005963 | Up | miR-122/PKM2 | Colorectal cancer | [118] |
| 2. | Palbociclib | Thymidine Kinase 1 (TK1), CDK9 | Up | - | Breast cancer | [119] |
| 3. | 5-fluorouracil (5-FU) | p-STAT3 and GSTP1 | Up | - | Colorectal Cancer | [120] |
| 4. | Temozolomide (TMZ) | lncRNA SBF2-AS1 | Up | miR-151a-3p/XRCC4 | Glioblasto ma | [121] |
| miR-1238 | Up | CAV1/EGFR | Glioblasto ma | [122] | ||
| 5. | Docetaxel | miR-9–5p, miR-195–5p, miR-203a-3p | Up | ONECUT2 | Breast cancer | [123] |
| 6. | Doxorubicin | miR-501–5p | Up | BLID | Gastric cancer | [79] |
| 7. | Melphalan or Bortezomib | Acid sphingomyelina se (ASM) | Up | Concerts sphingomyel in into ceramide | Multiple myeloma | [124] |
| 8. | Vincristine | Chloride intracellular channel 1 (CLIC1) | Up | - | Gastric cancer | [125] |