Fig. 8.

Microviridins and other OEPs discovered by genome mining. Microviridins were isolated via heterologous expression of mdnABCDE gene cluster in E. coli. Arg in C-terminal Trp was highlighted in bold, indicating the differences between microviridin B and microviridin J in their cyclic region. OEP-4-1, OEP-5-1 and OEP-6-1 BGCs were derived from Sphingobacteriales bacterium 44–61, Vibrio sp. JCM 18905 and Chryseobacterium greenlandense UMB34, respectively. The mature peptides were obtained via heterologous expression of the corresponding gene clusters in E. coli.