Table 3.

Aerosolization and inhalation profiles of chitosan nanoparticles in lactose-PEG3000 microparticles.

	F1	F2	F3	F4	F5	F6
MMAD (µm)	4.13 ± 0.59	4.25 ± 0.85	4.40 ± 0.85	4.70 ± 0.16	7.65 ± 0.90	3.85 ± 0.47
GSD	4.27 ± 1.41	5.14 ± 0.35	1.76 ± 0.12	2.11 ± 0.65	4.23 ± 0.47	3.71 ± 0.95
TD (mg)	15	15	15	15	15	15
ED (mg)	12.34 ± 1.18	12.41 ± 1.79	10.11 ± 1.69	12.81 ± 0.84	12.33 ± 1.97	11.78 ± 0.37
DD (mg)	5.46 ± 0.93	6.66 ± 1.33	4,38 ± 0.58	4.45 ± 1.25	5.85 ± 1.10	4.84 ± 0.59
PD (%)	82.29 ± 7.87	82.74 ± 11.99	67.45 ± 11.29	85.37 ± 5.64	82.18 ± 13.11	78.52 ± 2.47
PI (%)	36.42 ± 6.22	44.43 ± 8.84	29.22 ± 3.88	29.69 ± 8.39	38.98 ± 7.36	32.29 ± 3.95
Particles < 4.5 µm
FPD (mg)	3.82 ± 0.72	4.63 ± 1.16	2.81 ± 0.69	2.71 ± 0.99	3.40 ± 0.87	3.82 ± 0.32
FPF (%)	30.83 ± 3.89	36.96 ± 4.64	27.54 ± 2.48	20.92 ± 6.69	27.31 ± 3.01	32.42 ± 2.07
RF (%)	69.79 ± 1.24	69.01 ± 3.98	63.45 ± 7.47	59.98 ± 7.15	57.69 ± 5.19	79.14 ± 3.17
Particles < 3.6 µm
FPD (mg)	1.98 ± 0.39	2.78 ± 0.85	1.12 ± 0.45	1.16 ± 0.54	1.29 ± 0.34	1.70 ± 0.28
FPF (%)	15.94 ± 1.63	22.15 ± 4.25	10.90 ± 3.02	9.04 ± 3.91	10.31 ± 1.24	14.33 ± 2.05
RF (%)	36.26 ± 3.37	41.23 ± 5.05	25.01 ± 6.94	26.68 ± 10.07	21.76 ± 2.01	34.80 ± 1.50
0.5 µm < Particles < 3.6 µm
FPD (mg)	1.38 ± 0.68	1.98 ± 0.61	0.99 ± 0.42	1.04 ± 0.47	1.07 ± 0.24	1.17 ± 0.56
FPF (%)	12.93 ± 4.39	15.75 ± 3.08	9.73 ± 3.25	8.09 ± 3.49	9.59 ± 0.66	10.92 ± 4.59
RF (%)	26.99 ± 9.83	29.31 ± 3.70	22.25 ± 7.13	24.25 ± 10.57	19.16 ± 1.08	25.77 ± 9.17