Fig. 4.

A) Alignment of LovB and EryKS1 used in the mutagenesis experiment reported by Khosla and coworkers to identify conserved residues between modular and iterative PKSs essential for catalysis. Residues mutated in the report are indicated in yellow and residues found within 10 Å of the active site cysteine are in boxes. The alignment was performed with MUSCLE. B) Homology Model of EryKS1 with the residues mutated by Khosla and coworkers highlighted in blue. The homology model was made with Swiss PDB using EryKS3 as a template.