Table 1 |.
Cell type | Functions of TIm3 |
---|---|
CD8+ DCs | Facilitates the uptake of apoptotic material and enhances antigen cross-p resentation39 |
Tumour-associated DCs | Inhibits the activation of nucleic acid sensing TLRs41 |
Reduces CXCL9 secretion by tumour cDC1s and dampens CD8+ T cell cytotoxicity indirectly119 | |
Macrophages | Regulates the response to TLR2 and TLR4 stimulation; is upregulated on macrophages in sepsis and downregulated in severe sepsis113 |
Inhibits the release of proinflammatory cytokines in DSS colitis114 | |
Interacts with STAT1, which leads to miR-155 expression116 | |
Interacts with NRF2, leading to reduced expression of CD36 and the haem oxygenase 1–IL-1β pathway; in experimental Listeria monocytogenes infection, this results in reduced ingestion of bacteria117 | |
Mast cells | Mediates mast cell activation following IgE sensitization and antigen-dependent activation7,135 |
NK cells | May promote dysfunction in cancer6,127 |
Induces maternal–fetal tolerance130–132 |
cDC1, type 1 conventional dendritic cell; CXCL9, CXC-chemokine ligand 9; DC, dendritic cell; DSS, dextran sodium sulfate; NK cell, natural killer cell; NRF2, nuclear factor erythroid 2-related factor 2; STAT1, signal transducer and activator of transcription 1; TLR, Toll-like receptor.