. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Nat Rev Immunol. 2019 Nov 1;20(3):173–185. doi: 10.1038/s41577-019-0224-6

Table 1 |.

The role of TIm3 in non-T cell leukocytes

Cell type	Functions of TIm3
CD8⁺ DCs	Facilitates the uptake of apoptotic material and enhances antigen cross-p resentation³⁹
Tumour-associated DCs	Inhibits the activation of nucleic acid sensing TLRs⁴¹
Tumour-associated DCs	Reduces CXCL9 secretion by tumour cDC1s and dampens CD8⁺ T cell cytotoxicity indirectly¹¹⁹
Macrophages	Regulates the response to TLR2 and TLR4 stimulation; is upregulated on macrophages in sepsis and downregulated in severe sepsis¹¹³
	Inhibits the release of proinflammatory cytokines in DSS colitis¹¹⁴
	Interacts with STAT1, which leads to miR-155 expression¹¹⁶
	Interacts with NRF2, leading to reduced expression of CD36 and the haem oxygenase 1–IL-1β pathway; in experimental Listeria monocytogenes infection, this results in reduced ingestion of bacteria¹¹⁷
Mast cells	Mediates mast cell activation following IgE sensitization and antigen-dependent activation^7,135
NK cells	May promote dysfunction in cancer^6,127
NK cells	Induces maternal–fetal tolerance^130–132

cDC1, type 1 conventional dendritic cell; CXCL9, CXC-chemokine ligand 9; DC, dendritic cell; DSS, dextran sodium sulfate; NK cell, natural killer cell; NRF2, nuclear factor erythroid 2-related factor 2; STAT1, signal transducer and activator of transcription 1; TLR, Toll-like receptor.