Table 2.
Mean DT MRI measures of the selected WM regions of interest (ROIs) in ALS patients and healthy controls (HC).
| Variable | HC | ALS patients | p | |
|---|---|---|---|---|
| FA CC-body | 0.684 ± 0.04 | 0.664 ± 0.037 | 0.008 | |
| FA Bulbo-pontine CST | 0.618 ± 0.035 | 0.599 ± 0.033 | 0.008 | |
| FA Cerebral peduncle | 0.712 ± 0.023 | 0.69 ± 0.025 | <0.001 | |
| FA Posterior internal capsule | 0.69 ± 0.024 | 0.671 ± 0.025 | <0.001 | |
| FA Superior corona radiata | 0.49 ± 0.028 | 0.471 ± 0.022 | <0.001 | |
| MD CC-body | 0.84 ± 0.059 | 0.847 ± 0.057 | 0.600 | |
| MD Bulbo-pontine CST | 0.685 ± 0.042 | 0.695 ± 0.03 | 0.212 | |
| MD Cerebral peduncle | 0.718 ± 0.031 | 0.722 ± 0.032 | 0.639 | |
| MD Posterior internal capsule | 0.704 ± 0.022 | 0.714 ± 0.024 | 0.048 | |
| MD Superior corona radiata | 0.719 ± 0.028 | 0.736 ± 0.030 | 0.008 | |
| axD CC-body | 1.641 ± 0.067 | 1.618 ± 0.067 | 0.06 | |
| axD Bulbo-pontine CST | 1.21 ± 0.067 | 1.204 ± 0.067 | 0.553 | |
| axD Cerebral peduncle | 1.425 ± 0.071 | 1.406 ± 0.055 | 0.082 | |
| axD Posterior internal capsule | 1.374 ± 0.055 | 1.366 ± 0.044 | 0.293 | |
| axD Superior corona radiata | 1.143 ± 0.047 | 1.151 ± 0.048 | 0.542 | |
| radD CC-body | 0.449 ± 0.083 | 0.461 ± 0.063 | 0.428 | |
| radD Bulbo-pontine CST | 0.432 ± 0.083 | 0.44 ± 0.03 | 0.610 | |
| radD Cerebral peduncle | 0.367 ± 0.058 | 0.38 ± 0.031 | 0.206 | |
| radD Posterior internal capsule | 0.377 ± 0.059 | 0.389 ± 0.027 | 0.255 | |
| radD Superior corona radiata | 0.518 ± 0.08 | 0.529 ± 0.027 | 0.484 |
Values are reported as mean ± standard deviation. Differences between ALS patients and healthy controls were assessed using a Multivariate Analysis of Covariance (MANCOVA) test, adjusting for sex and age and applying Bonferroni correction. Abbreviations: ALS = amyotrophic lateral sclerosis; axD = axial diffusivity; CC = corpus callosum; CST = corticospinal tract; FA = fractional anisotropy; MD = mean diffusivity; HC = healthy controls; radD = radial diffusivity.
Bold is for significant values