Table 1a.

Model input parameters – Probabilities and Health utilities.

	Base case*	Range	Distributionβ	Sources
Effectiveness data
FMT-NGT
Response rate – single infusion	0.81	0.73–0.88	Beta (422, 331)	[6,20,25,33]
Response rate- multiple infusion	0.88	0.82–0.94	Beta (4,8)	[6,25,33]
Recurrence rate	0.12	0.06–0.30	Beta (4, 32)	[15,16,20]
FMT - colonoscopy
Response rate - single infusion	0.87	0.79–0.94	Beta (597, 432)	[20,25,33,50]
Response rate- multiple infusion	0.95	0.92–0.97	Beta (25,30)	[25,33,50]
Recurrence rate	0.09	0.06–0.30	Beta (3, 26)	[15,16,51]
Fidaxomicin
Response rate	0.42	0.22–0.88	Beta (7,14)	[20,22]
Recurrence rate	0.15	0.12–0.50	Beta (3,18)	[5,19,22]
Vancomycin
Response rate	0.31	0.19–0.75	Beta (6,16)	[6,19,20,50]
Recurrence rate	0.31	0.21–0.70	Beta (12,23)	[6,19,22,52]
Vancomycin TP
Response rate	0.58	0.40–0.81	Beta (25,30)	[49,53]
Recurrence rate	0.31	0.10–0.40	Beta (25,30)	[52,53]
Mortality
CDI related mortality	0.18	0.15–0.30	Beta (9, 87)	[9,27]
Other cause mortality – 65 years	0.002	-	Fixed	[26]
Utilities- QALYs
Cured - 65 years	0.78	0.70–1.00	Beta (21,6)	[28]
Relapsed CDI	0.42	0.35–0.81	Beta (77,107)	[8]
rCDI	0.42	0.35–0.81	Beta (77,107)	[8]
Dead	0	0	0

Abbreviations: FMT, Feacal Microbiota Transplant; NGT, Nasogastric Tube; TP, Taper Pulsed; QALYs, Quality Adjusted Life Years; CDI, Clostridioids Difficile infection; rCDI, recurrent Clostridioids Difficile infection.

β Probabilistic sensitivity analysis, alpha and beta values for Beta distribution.