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Jaccard-based analysis of microbial shifts during and after antibiotic perturbation. (A) PCoA based on the Jaccard metric of days 0, 14, 21, 71, and 86 of 1-year-old WT and Nod2-KO mice. (B) Jaccard distance of samples from d14, d21, d71, and d86 from d0 (baseline). A smaller distance indicates more similar microbial communities. ∗∗P < .005, Mann–Whitney test. (C) PCoA using the Jaccard metric of days 0, 10, 20, and 50 of 20-week-old WT and Nod2-KO mice.
