Fig. 3.

RNA editing sites in Ess and Noness genes. (A, D) Differences in the number of Ess genes between edited and unedited genes (P = 0.0003 in A; P < 0.0001 in D). The unedited genes here refer to the genes we obtained from OGEE and GIC, which are not present in the edited gene sets we have detected. (B, E) Edited gene numbers in CDSs are different between Ess and Noness genes (P = 0.2851 in B; P = 0.3795 in E). (C, F) The editing level in Ess genes is lower than in Noness genes. The results of human (A–C) and of mouse (D–F) are shown. The P values are from χ² tests (A, B, D, E) and from F test (C, F). Ess, Essential; Noness, Non‐essential; nonsy, predicted nonsynonymous substitution; sy, predicted synonymous substitution.