Table 2.
GO analysis for genes that produced nonsynonymous editing. Only significant GO terms with an enrichment value P < 0.005 are presented.
| Species | GO_term | Example gene | P‐value | No. of genes |
|---|---|---|---|---|
| Human | Regulation of chromosome organization | APC/RIF1/JARID2 | 0.000286512 | 3 |
| Regulation of histone methylation | RIF1/JARID2 | 0.000787868 | 2 | |
| Maintenance of cell number | TBX3/RIF1/POU5F1 | 0.001130463 | 3 | |
| Embryonic germ layer development | INHBA/DVL1/POU5F1/BMPR2/ACVR2A/AXIN1 | 4.89E−8 | 6 | |
| Regulation of signaling pathway | APC/DVL1/FZD6/AXIN1 | 3.62E−5 | 4 | |
| Stem cell population maintenance | TBX3/RIF1/POU5F1 | 0.00079208 | 3 | |
| Regulation of stem cell proliferation | TBX3/PAX6 | 8.80E−5 | 2 | |
| Pig | Lipid metabolic process | ACLY/CLN3/AGK/PTGR1/FAR1/PNPLA4/HADHA | 4.52E−5 | 67 |
| Cellular lipid metabolic process | CLN3/AGK/PTGR1/PNPLA4/HADHA | 0.00054275 | 48 | |
| Alcohol metabolic process | PMVK/HMGCR/LDLR/CYP7A1/INSIG2/PRKAA2 | 0.000344265 | 21 | |
| Organic acid catabolic process | HYAL2/HADHA/DLST/ETFB/GOT1/AMT | 0.000512426 | 16 | |
| Cell development and differentiation | PRKAR2A/FZR1/PRKAR1A/GDF9/PDE3A | 4.17E−6 | 12 | |
| Ion homeostasis | CLN3/NUBP1/SFXN1/ATP1A1/SLC9A1 | 0.000277434 | 37 | |
| Multiorganism reproductive process | PRKAR2A/FZR1/PRKAR1A/GDF9/CD46 | 0.00055712 | 43 | |
| Regulation of cell maturation | PRKAR2A/FZR1/PRKAR1A/GDF9/CDC20 | 3.15E−5 | 11 | |
| Mouse | DNA repair | Usp1/Ticrr/Smc4/Rbbp8/Uhrf1/Pnp | 3.6632436754777E−11 | 35 |
| RNA transport | Tpr/Alkbh5/Nup214/Xpo5/Seh1L/Ahctf1 | 0.000177271 | 15 | |
| Interkinetic nuclear migration | Tacc3/Hhex/Hook3/Dock7 | 2.83E−583374166 | 4 | |
| In utero embryonic development | Ttn/Cnot1/Acvr1/E2f8/Tbx3/Hectd1/Chd7 | 0.001310038 | 7 | |
| Multicellular organism growth | Celf1/Chd7/Rmi1/H2‐Q2/Daxx | 0.00216228 | 20 | |
| Antigen processing | H2‐Dmb2/H2‐Dmb1/H2‐Dma/H2‐Q1/H2‐Q2 | 3.01E−6 | 18 |