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Ligand-biased signaling via formyl peptide receptors. A variety of ligands (e.g., lipoxin A4 (LXA4) and resolvin D1 (RvD1)) induce FPR2/ALX homodimerization and FPR2/FPR1 dimerization and lead to the activation of different downstream signaling cascades. Oligomerization is not limited to FPR family members and includes even non-GPCR surface receptors, such as the scavenger receptor MARCO. PMN: polymorphonuclear leukocyte.
