Table 1.
General characteristics of study subjects.
| Variable | Control (n = 40) | T2DM (n = 35) | T2DM + CAS (n = 35) | P |
|---|---|---|---|---|
| Sex (M/F) | 19/21 | 19/16 | 19/16 | 0.791 |
| Smoker (Y/N) | 6/34 | 9/26 | 13/22 | 0.090 |
| Drinker (Y/N) | 5/35 | 7/28 | 8/27 | 0.482 |
| Age (year) | 50.73 ± 11.18 | 50.57 ± 9.89 | 55.69 ± 10.56*# | 0.072 |
| BMI (kg/m2) | 23.29 ± 2.44 | 23.95 ± 3.44 | 25.20 ± 3.17** | <0.001 |
| SBP (mmHg) | 118.28 ± 10.61 | 128.80 ± 12.03** | 138.57 ± 14.83**## | <0.001 |
| DBP (mmHg) | 73.50 ± 10.00 | 78.00 ± 10.00 | 71.00 ± 12.00 | 0.415 |
| FBG (mmol/L) | 4.80 ± 0.48 | 7.77 ± 2.29** | 7.44 ± 3.01** | <0.001 |
| Insulin (μU/ml) | 7.75 ± 2.08 | 10.40 ± 3.60** | 10.20 ± 3.20** | <0.001 |
| HOMA-IR | 1.66 ± 0.47 | 3.55 ± 1.91** | 3.56 ± 1.58** | <0.001 |
| HbA1c (%) | 4.90 ± 0.58 | 8.00 ± 3.10** | 7.90 ± 2.10** | <0.001 |
| TG (mmol/L) | 1.46 ± 0.94 | 1.48 ± 1.42 | 2.01 ± 1.65* | 0.012 |
| TC (mmol/L) | 4.17 ± 1.19 | 4.94 ± 1.22** | 4.93 ± 1.47* | 0.004 |
| LDL-C (mmol/L) | 2.08 ± 0.59 | 2.64 ± 1.12* | 2.89 ± 1.03** | <0.001 |
| HDL-C (mmol/L) | 1.40 ± 0.29 | 1.16 ± 0.29** | 1.04 ± 0.22** | <0.001 |
| ALT (U/L) | 13.25 ± 6.75 | 24.30 ± 23.6** | 17.40 ± 11.90* | <0.001 |
| AST (U/L) | 18.80 ± 5.68 | 22.10 ± 11.00 | 20.20 ± 6.60 | 0.066 |
| ESR (mm/h) | 13.00 ± 10.00 | 14.00 ± 8.00 | 11.00 ± 11.00 | 0.879 |
| hsCRP (mg/L) | 1.95 ± 1.60 | 2.31 ± 2.60 | 2.71 ± 3.64 | 0.201 |
| CTRP5 (ng/ml) | 100.21 ± 37.94 | 168.48 ± 39.25** | 230.93 ± 34.97**## | <0.001 |
*P < 0.05, **P < 0.01 Comparison with Control.
#P < 0.05.
##P < 0.01 Comparison with T2DM.
Data are mean ± SD. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood-glucose; HOMA-IR, homeostasis model insulin resistance index; HbA1c, glycated hemoglobin A1c; TG, riglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ALT, alanine aminotransferase; AST, aspartic aminotransferase; ESR, erythrocyte sedimentation rate; hsCRP, highsensitive C-reactive protein; CTRP5, C1q/TNF-related protein 5.