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Novel Mechanism: Reactive oxygen species (ROS)-related mechanisms, regulated by ROS generating enzyme NADPH oxidase 2 (NOX2) and antioxidant transcription factor Nrf2 pathways, modulated the secretomic changes during kidney dysfunction. The modulation was closely related to the balance of ROS and antioxidants and the imbalance contributes to the alteration of ROS-dependent SGs which could promote disease progression.
