Table 1a.
Middle class uremic toxins (UTs) classified into secretomic proteins and non-secretomic toxins from the EUTox Work Group (http://www.uremic-toxins.org/). Middle class UTs defined as molecular weight >500 Daltons. All 2641 Secretomic Genes (SGs) and UTs are listed in Supplement Table 1.
| name | related gene symbol | |
|---|---|---|
| Secretomic UTs (86.67%) | Adiponectin | ADIPOQ |
| Adrenomedullin | ADM | |
| Atrial Natriuretic Peptide (ANP) | NPPA | |
| Basic fibroblast growth factor (BFGF) | FGF2 | |
| Calcitonin gene-related peptide (CGRP) | CALCA | |
| Cholecystokinin | CCK | |
| Clara cell protein (CC16) | SCGB1A1 | |
| Complement Factor D | CFD | |
| Cystatin C | CST3 | |
| Endothelin | EDN1, EDN2, EDN3 | |
| Guanylin | GUCA2A,GUCA2B, GUCA2C | |
| Interleukin-18 | IL18 | |
| Interleukin-1β | IL1B | |
| Interleukin-6 | IL6 | |
| Methionine-Enkephalin | PENK | |
| Motiline | MLN | |
| Neuropeptide Y | NPY | |
| Parathyroid hormone | PTH | |
| Resistin | RETN | |
| Substance P | TAC1 | |
| Tumor Necrosis Factor Alpha (TNF) | TNF | |
| Uroguanylin | GUCA2A, GUCA2B | |
| Vasoactive intestinal peptide (VIP) | VIP | |
| Vasopressin (ADH) | AVP | |
| β-2-Microglobulin | B2M | |
| β-Endorphin |
POMC |
|
| Degranulation Inhibiting Protein I | ||
| non-secretomic UTs (13.33%) | Delta-sleep Inducing Peptide | TSC22D3 |
| Hyaluronic acid (Hyaluronan) | HAS1,HAS2 | |
| λ-Ig Light Chain | IGLC1, IGLC2, IGLC3, IGLC7 | |