Table 4c.
The IPA classified the parts of the SGs modulated in the PBMCs from patients with CKD and patients with ESRD as the cytokine group. The results showed that 4 out of 55 SGs (7.2%) downregulated in CKD (also shown in Table 2B) were cytokines; one out of 44 SGs (2.27%) upregulated in CKD was cytokine; 68 out of 928 SGs (7.3%) downregulated in ESRD were cytokines; and 6 out of 121 SGs (4.96%) upregulated in ESRD were cytokines.
| Symbol | Entrez Gene Name | Expr p-value | Expr Log Ratio | Location | |
|---|---|---|---|---|---|
| down in CKD | IL24 | interleukin 24 | 0.0327 | −1.174 | Extracellular Space |
| [4] | IL36RN | interleukin 36 receptor antagonist | 0.0319 | −1.2 | Extracellular Space |
| PF4 | platelet factor 4 | 0.0149 | −1.11 | Extracellular Space | |
| EDA |
ectodysplasin A |
0.00949 |
−1.069 |
Plasma Membrane |
|
| up in CKD (1) |
DKK3 |
dickkopf WNT signaling pathway inhibitor 3 |
0.0094 |
1.827 |
Extracellular Space |
| down in ESRD | BMP8A | bone morphogenetic protein 8a | 0.000409 | −2.355 | Extracellular Space |
| [68] | CCL1 | C–C motif chemokine ligand 1 | 0.0184 | −1.28 | Extracellular Space |
| CCL8 | C–C motif chemokine ligand 8 | 0.0221 | −1.682 | Extracellular Space | |
| CCL13 | C–C motif chemokine ligand 13 | 5.57E-05 | −1.797 | Extracellular Space | |
| CCL17 | C–C motif chemokine ligand 17 | 0.0196 | −1.465 | Extracellular Space | |
| CCL18 | C–C motif chemokine ligand 18 | 0.00866 | −1.367 | Extracellular Space | |
| CCL19 | C–C motif chemokine ligand 19 | 0.0044 | −2.113 | Extracellular Space | |
| CCL21 | C–C motif chemokine ligand 21 | 0.00242 | −2.011 | Extracellular Space | |
| CCL22 | C–C motif chemokine ligand 22 | 3.47E-05 | −1.656 | Extracellular Space | |
| CCL23 | C–C motif chemokine ligand 23 | 0.00434 | −2.54 | Extracellular Space | |
| CCL24 | C–C motif chemokine ligand 24 | 0.00354 | −1.942 | Extracellular Space | |
| CCL25 | C–C motif chemokine ligand 25 | 0.0037 | −1.042 | Extracellular Space | |
| CRH | corticotropin releasing hormone | 0.00196 | −1.518 | Extracellular Space | |
| CSF1 | colony stimulating factor 1 | 7.44E-05 | −1.84 | Extracellular Space | |
| CSF2 | colony stimulating factor 2 | 0.00115 | −1.158 | Extracellular Space | |
| CX3CL1 | C-X3-C motif chemokine ligand 1 | 0.00352 | −1.231 | Extracellular Space | |
| CXCL5 | C-X-C motif chemokine ligand 5 | 0.0264 | −1.939 | Extracellular Space | |
| CXCL9 | C-X-C motif chemokine ligand 9 | 0.014 | −1.063 | Extracellular Space | |
| CXCL11 | C-X-C motif chemokine ligand 11 | 0.0439 | −1.101 | Extracellular Space | |
| CXCL12 | C-X-C motif chemokine ligand 12 | 0.000564 | −1.422 | Extracellular Space | |
| CXCL14 | C-X-C motif chemokine ligand 14 | 0.00645 | −1.535 | Extracellular Space | |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.00168 | −1.867 | Extracellular Space | |
| EDN1 | endothelin 1 | 0.0271 | −1.424 | Extracellular Space | |
| EPO | erythropoietin | 0.00154 | −2.113 | Extracellular Space | |
| FASLG | Fas ligand | 0.000484 | −1.074 | Extracellular Space | |
| IFNA5 | interferon alpha 5 | 0.0351 | −1.309 | Extracellular Space | |
| IFNA7 | interferon alpha 7 | 0.0259 | −1.167 | Extracellular Space | |
| IFNA16 | interferon alpha 16 | 0.0243 | −1.327 | Extracellular Space | |
| IFNB1 | interferon beta 1 | 0.0248 | −1.679 | Extracellular Space | |
| IFNW1 | interferon omega 1 | 0.000648 | −1.794 | Extracellular Space | |
| IL2 | interleukin 2 | 0.00237 | −1.245 | Extracellular Space | |
| IL3 | interleukin 3 | 0.00158 | −1.82 | Extracellular Space | |
| IL4 | interleukin 4 | 0.000549 | −2.658 | Extracellular Space | |
| IL5 | interleukin 5 | 0.00255 | −1.791 | Extracellular Space | |
| IL9 | interleukin 9 | 0.00207 | −1.852 | Extracellular Space | |
| IL11 | interleukin 11 | 0.00046 | −1.87 | Extracellular Space | |
| IL16 | interleukin 16 | 0.000374 | −1.476 | Extracellular Space | |
| IL19 | interleukin 19 | 0.00647 | −1.564 | Extracellular Space | |
| IL21 | interleukin 21 | 0.000431 | −2.258 | Extracellular Space | |
| IL22 | interleukin 22 | 0.0124 | −1.315 | Extracellular Space | |
| IL24 | interleukin 24 | 0.000213 | −2.527 | Extracellular Space | |
| IL25 | interleukin 25 | 0.00486 | −1.597 | Extracellular Space | |
| IL26 | interleukin 26 | 0.00285 | −1.789 | Extracellular Space | |
| IL37 | interleukin 37 | 0.031 | −1.296 | Extracellular Space | |
| IL17A | interleukin 17A | 0.0004 | −1.944 | Extracellular Space | |
| IL1A | interleukin 1 alpha | 1.52E-07 | −2.584 | Extracellular Space | |
| IL1RN | interleukin 1 receptor antagonist | 4.04E-05 | −1.628 | Extracellular Space | |
| IL36A | interleukin 36 alpha | 0.00185 | −1.492 | Extracellular Space | |
| IL36G | interleukin 36 gamma | 0.0143 | −1.615 | Extracellular Space | |
| IL36RN | interleukin 36 receptor antagonist | 0.0281 | −1.175 | Extracellular Space | |
| LIF | LIF interleukin 6 family cytokine | 0.0323 | −1.402 | Extracellular Space | |
| LTA | lymphotoxin alpha | 2.73E-05 | −2.497 | Extracellular Space | |
| OSM | oncostatin M | 0.00294 | −2.002 | Extracellular Space | |
| PF4 | platelet factor 4 | 0.0432 | −1.106 | Extracellular Space | |
| PRL | prolactin | 0.00443 | −1.693 | Extracellular Space | |
| PRLH | prolactin releasing hormone | 0.00346 | −1.191 | Extracellular Space | |
| SCG2 | secretogranin II | 0.00633 | −2.162 | Extracellular Space | |
| SCGB1A1 | secretoglobin family 1A member 1 | 0.0166 | −1.372 | Extracellular Space | |
| SLURP1 | secreted LY6/PLAUR domain containing 1 | 0.000616 | −1.435 | Extracellular Space | |
| SPP1 | secreted phosphoprotein 1 | 0.000139 | −2.907 | Extracellular Space | |
| THPO | thrombopoietin | 0.00506 | −1.895 | Extracellular Space | |
| TNFSF11 | TNF superfamily member 11 | 0.000298 | −1.936 | Extracellular Space | |
| TNFSF14 | TNF superfamily member 14 | 1.85E-05 | −3.778 | Extracellular Space | |
| WNT1 | Wnt family member 1 | 0.00424 | −1.889 | Extracellular Space | |
| WNT2 | Wnt family member 2 | 0.0082 | −1.681 | Extracellular Space | |
| WNT4 | Wnt family member 4 | 0.00799 | −1.371 | Extracellular Space | |
| WNT5A | Wnt family member 5A | 0.00932 | −2.049 | Extracellular Space | |
| EDA |
ectodysplasin A |
3.23E-06 |
−1.747 |
Plasma Membrane |
|
| up in ESRD | AIMP1 | aminoacyl tRNA synthetase complex interacting multifunctional protein 1 | 8.15E-09 | 1.927 | Extracellular Space |
| [6] | CXCL2 | C-X-C motif chemokine ligand 2 | 0.000396 | 3.051 | Extracellular Space |
| CXCL8 | C-X-C motif chemokine ligand 8 | 1.78E-06 | 4.136 | Extracellular Space | |
| IL7 | interleukin 7 | 0.0188 | 1.258 | Extracellular Space | |
| IL15 | interleukin 15 | 5.13E-06 | 1.645 | Extracellular Space | |
| XCL1 | X–C motif chemokine ligand 1 | 0.00893 | 1.131 | Extracellular Space |