Table 4d.

Proinflammatory and profibrotic molecules, pathways and transcription factors played important roles in pathophysiological process of ESRD.

Method	Table/Figure	Result
IPA	Fig. 2B	upregulated SGs in ESRD can active proinflammatory pathways such as IL8 signaling, neuroinflammation signaling pathway.
IPA	Fig. 2D	downregulated SGs in ESRD can active profibrotic pathways such as inhibition of matrix metalloporteases
TRANSFAC	Table 3C	upregulated SGs in ESRD may be modulated by transcription factors involved in inflammation and fibrosis (Egr-1, POU1F1)
ClueGo	Fig. 3B	UT-encoded genes and up-regulated SGs in ESRD are shared in some pro-inflammatory pathways。
GEO2R	Table 4a, Table 4bA and 4B	Proinflammatory uremic cytokines IL1b and IL18 in UTs can amplify the upregulation of SGs in ESRD
IPA	Table4C	Cytokines can be modulated during CKD progression to induce imbalance of anti-inflammatory and proinflammatory function.