Table 6.
A Eight out of 44 SGs (18.18%) upregulated in CKD were found in M1 macrophage polarization dataset; and six out of 44 SGs (13.64%) upregulated in CKD were found in M2 macrophage polarization. 15 out of 121 SGs (12.4%) upregulated in ESRD were found in M1 macrophage polarization dataset; 16 out of 121 SGs (13.2%) were found in M2 macrophage polarization. These results suggest that macrophage polarization pathways participate CKD-, and ESRD-upregulated secretomic changes in the PBMCs in patients with CKD and ESRD (PMID: 30827512).
| GEO ID |
GSE85346 |
M2 (6) |
||||||
|---|---|---|---|---|---|---|---|---|
| M1 (8) | ||||||||
| M1/M0 |
M2a/M0 |
M2b/M0 |
M2c/M0 |
|||||
| Gene Symbol | Log FC | Gene Symbol | Log FC | Gene Symbol | FC | Gene Symbol | Log FC | |
| CKD | ADAM23 | 3.347203 | APCS | 1.077464 | C3 | 2.819101 | S100A12 | 2.702538 |
| APCS | 2.623466 | CELA2B | 1.065595 | CELA2B | 1.216281 | |||
| CGREF1 | 3.072414 | PLA2G5 | 1.280399 | S100A12 | 4.50631 | |||
| LAMB1 | 3.023362 | TNFAIP6 | 5.233126 | |||||
| NRP2 | 1.740985 | |||||||
| PI3 | 3.458997 | |||||||
| S100A12 | 3.80053 | |||||||
| TNFAIP6 |
8.844792 |
|||||||
| M1 (15) |
M2 (16) |
|||||||
| ESRD | CD44 | 1.014886 | CTSC | 3.295263 | ASGR1 | 1.066338 | CTSC | 1.434133 |
| CD48 | 1.739752 | C3 | 2.819101 | DSE | 1.554709 | |||
| CXCL2 | 2.43399 | CTSC | 1.612899 | HEG1 | 1.066944 | |||
| DSE | 1.893179 | CXCL2 | 2.70138 | IL7 | 2.068031 | |||
| EREG | 3.423501 | IRAK3 | 1.930381 | MGAT4A | 1.202096 | |||
| IGFBP7 | 1.388798 | PTX3 | 1.792836 | S100A12 | 2.702538 | |||
| IL15 | 2.544436 | RETN | 4.306012 | S100A8 | 3.187036 | |||
| IRAK3 | 1.341773 | RNASE2 | 1.692809 | VCAN | 2.876119 | |||
| MGAT4A | 1.055701 | S100A12 | 4.50631 | XCL1 | 1.001179 | |||
| MTHFD2 | 1.605983 | S100A8 | 5.25634 | |||||
| PTX3 | 3.304702 | VCAN | 1.791611 | |||||
| S100A12 | 3.80053 | |||||||
| S100A8 | 3.323343 | |||||||
| TXN | 1.426231 | |||||||
| VEGFA | 2.795328 | |||||||