Table 7.

Among all SGs we investigated, no senescence regulators out of 71 were upregulated in CKD; two out of 71 senescence regulator genes such as Inhibitor Of DNA Binding 1 (ID1) and secreted protein acidic and rich in cysteine (SPARC) were downregulated in CKD; two out of 71 senescence regulator genes such as Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) and Insulin Like Growth Factor Binding Protein 7 (IGFBP7) were upregulated in ESRD while five were downregulated in ESRD such as Serpin Family E Member 1 (SERPINE1), SPARC, transforming growth factor b1 (TGFB1), insulin-like growth factor (IGF1) and Insulin Like Growth Factor Binding Protein 5 (IGFBP5).

Group	Gene Symbol	p value	log FC	Function
Upregulated in CKD	N/A
Downregulated in CKD	ID1	0.042591	−1.10654	p53/pRb signaling & cell cycle
	SPARC	0.028006	−1.00435	p53/pRb signaling & cell cycle
Upregulated in ESRD	CREG1	7.63E-05	1.463896	p53/pRb signaling & cell cycle
	IGFBP7	5.81E-05	2.059804	Interferon Signaling; insulin growth factor related
Downregulated in ESRD	SERPINE1	0.0234	−1.17965	Other Senescence Response Gene
	SPARC	0.00428	−1.93975	p53/pRb signaling & cell cycle
	TGFB1	3.62E-06	−2.48915	p53/pRb signaling & cell cycle; Cell Adhesion Molecules
	IGF1	0.000375	−2.37204	insulin growth factor related
	IGFBP5	0.000673	−1.7563	insulin growth factor related