Table 8a.
Oxidative stress-related gene expressions (reactive oxygen species, ROS, regulatome) contributes to the progression of kidney dysfunction. We analyzed the gene expression of total 84 ROS regulatom84e (shown in supplement table 11) in CKD and ESRD. We found that 2 out of total 121 (1.65%) secretomic genes in ESRD while none of SGs in CKD are upregulated. Meanwhile, 8 out of 928 (0.8%) in ESRD and 1 out of 55 (1.82%) in CKD are downregulated.
| Group | Gene Symbol | p value | log FC |
|---|---|---|---|
| Upregulated in CKD |
N/A |
||
| Downregulated in CKD |
SOD3 |
0.031602 |
−1.04179 |
| Upregulated in ESRD | PRDX4 | 3.25E-05 | 1.308793 |
| PRNP |
8.80E-08 |
1.915437 |
|
| Downregulated in ESRD | GPX3 | 4.56E-04 | −1.13831 |
| GPX5 | 0.0101 | −1.48694 | |
| LPO | 0.00185 | −1.8362 | |
| MPO | 4.01E-03 | −1.85159 | |
| SOD3 | 0.0214 | −1.23203 | |
| IL19 | 0.00647 | −1.56396 | |
| IL22 | 0.0124 | −1.3153 | |
| APOE | 4.61E-06 | −1.78856 |