Fig. 6.

In vitro effects of DATS on XOR-derived NO are operative in vivo. Representative images demonstrating restoration of ischemic limb blood flow from CSE KO mice treated with DATS, Febx, or DATS + Febx (A) and quantification thereof (B). Total NO levels of Plasma (C) and ischemic and non-ischemic tissue of skeletal muscle (D) Vessel dilation (% change) in femoral artery at 30, 60 and 300 s in PBS, DATS, Febx + DATS or Febx alone. n = 4 and * = p<0.0001, # = p<0.005, ‡p = 0.007, & p = 0.0086.