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. 2020 May 26;23(6):101140. doi: 10.1016/j.isci.2020.101140

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Posterior View of the 3D Reconstructed Male Rat Heart

(A) Whole-heart view showing the context, extent, and distribution of the intrinsic cardiac neurons (ICN), located on superior and posterior surfaces of the atria.

(B–F) A higher-resolution view of the atria and blood vessels that are shown in (B), with various contoured features of heart anatomy that are selectively removed to appreciate the anatomical relationship of the ICN to (C) the pulmonary artery and superior vena cava (SVC), (D) the interatrial septum, (E) the left atrium and pulmonary veins, (F) the right atrium, where clusters #1 and #2 appear to be on the surface of both atria, whereas cluster #3, which is located around the border of the superior vena cava, left atrium, and right atrium, appears on the right atrium. (See also Video S2). Scale bars: panel A, 1000 μm; panels B–F, 500 μm.