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. 2020 Jun 24;9(6):bio053611. doi: 10.1242/bio.053611

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 9. — Gata6 regulates the number of ventricular cardiomyocytes. Shown are representative images of sibling wild-type (WT) (A) and gata6 null hearts (B) at 2 dpf derived from crossing Tg(myl7:gfp; myl7:dsREDnuc); gata6+/- adults and stained with S46 antibody to distinguish the atrium (blue). Scale bars: 0.1 mm. (C) Quantification of cardiomyocytes in each chamber shows a significant loss of ventricular cardiomyocytes in gata6 homozygous mutants (N=7 per genotype, t-test, P<0.0001, bars shown are s.e.m.). The number of atrial cells in the mutant remains unaffected compared to sibling controls, even though the atrial area is expanded.