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. 2020 Jun 22;147(12):dev178988. doi: 10.1242/dev.178988

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© 2020. Published by The Company of Biologists Ltd

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Fig. 2. — Notch1 deletion in TECs results in fewer TEPCs in the fetal thymus. (A-D) Immunofluorescence of E13.5 (A,B) and E16.5 (C,D) Foxn1^Cre;Notch1^fx/fx mutant (B,D) and control (A,C) thymi for CLD3,4 (red) and PLET1 (green). White arrows, PLET1⁺;CLD3,4⁻ cells; cyan arrows, PLET1⁻;CLD3,4⁺ cells; yellow arrows, PLET1⁺;CLD3,4⁺ cells. (E) Histogram showing CLD3⁺ cells in Foxn1^Cre;Notch1^fx/fx mutant and control thymi at E17.5. (F,G) Percentage (F) and total number (G) of CLD3⁺ TECs in mutant and control thymi at E17.5. ***P≤0.001, **P≤0.005. n>3 for IHC, n=5 for flow cytometry. Scale bars: 50 µm.