TABLE 1.

Proteotypic peptides used for apolipoprotein quantification

Protein	Molecular Mass (kDa)	Proteotypic Peptide	Concentration Range (μM)	LQC (μM)	MQC (μM)	HQC (μM)
ApoA-I	28.1	ATEHLSTLSEK	1–100	1	25	100
ApoA-II	9.3	SPELQAEAK	0.5–50	0.5	10	50
ApoA-IV	43.4	SELTQQLNALFQDK	0.5–50	0.5	10	50
ApoA-V	38.9	VQELQEQLR	0.01–1	0.01	0.25	1
ApoB48	240.8	LSQLQTYMI	0.01–1	0.01	0.25	1
ApoB100	512.9	ATGVLYDYVNK	0.1–10	0.1	2.5	10
ApoC-I	6.6	TPDVSSALDK	0.05–5	0.05	1	5
ApoC-II	8.2	TAAQNLYEK	0.25–25	0.25	5	25
ApoC-III	8.8	GWVTDGFSSLK	0.25–25	0.25	5	25
ApoC-IV	11.5	ELLETVVNR	0.05–5	0.05	1	5
ApoD	19.3	VLNQELR	0.1–10	0.1	2.5	10
ApoE	34.2	LGPLVEQGR	0.1–10	0.1	2.5	10
ApoE2	34.2	CLAVYQAGAR	0.1–10	0.1	2.5	10
ApoE4	34.2	LGADMEDVR	0.1–10	0.1	2.5	10
ApoE2/E3	34.2	LGADMEDVCGR	0.1–10	0.1	2.5	10
ApoE3/E4	34.2	LAVYQAGAR	0.1–10	0.1	2.5	10
ApoF	17.4	SGVQQLIQYYQDQK	0.05–5	0.05	1	5
ApoH	36.3	ATVVYQGER	0.1–10	0.1	2.5	10
ApoJ	50.1	ELDESLQVAER	0.1–10	0.1	2.5	10
ApoL1	41.1	VAQELEEK	0.05–5	0.05	1	5
ApoL1 (G0)	41.1	LNILNNNYK	0.05–5	0.05	1	5
ApoL1 (G1)	41.1	LNMLNNNYK	0.05–5	0.05	1	5
ApoL1 (G2)	41.1	LNILNNK	0.05–5	0.05	1	5
ApoM	21.3	AFLLTPR	0.1–10	0.1	2.5	10
Apo(a)	240–800	LFLEPTQADIALLK	0.005–0.5	0.005	0.1	0.5
Apo(a) Kr-IV2	12.5	GTYSTTVTGR	0.25–25	0.25	5	25

Molecular masses were adopted from UniProt (https://www.uniprot.org/) (signal peptides excluded from the calculation). Kr-IV₂, apo(a) kringle IV₂; LQC, low-concentration QC; MQC, middle-concentration QC; HQC, high-concentration QC.