TABLE 2.

Apolipoprotein concentrations in nonfasted individuals and matrix effect assessment

Apolipoprotein	EDTA Plasma (n = 160)				Serum (n = 160)	Li-Heparin Plasma (n = 72)	Citrate Plasma (n = 54)
	Male (n = 80)	Female (n = 80)	a	CV (%)
					b
ApoA-I	145 [126–160]	154 [133–178]	0.0016	5.6	+5.4	+1.2	−2.3
ApoA-II	33 [26–39]	34 [28–39]	0.5868	8.1	+37.2c	+29.4c	+17.3d
ApoA-IV	9 [8–11]	9 [11–13]	0.0002	10.1	−8.8c	−16.3c	−18.4c
ApoA-V	0.02 [0.01–0.06]	0.02 [0.01–0.04]	0.0452	11.3	+34.2c	+30.1c	+16.9c
ApoB48	1.4 [1.3–1.6]	1.7 [1.5–1.9]	0.0001	9.8	+12.1e	+9.5e	+11.5d
ApoB100	86 [68–100]	74 [55–96]	0.1059	4.8	+18.3c	+14.6c	+9.4d
ApoC-I	3.9 [3.1–4.9]	3.4 [2.6–4.0]	0.0024	2.4	+16.2b	+7.6e	+2.1
ApoC-II	5.5 [4.1–6.9]	4.4 [3.4–5.9]	0.0009	4.2	+8.3c	−5.6d	−16.4c
ApoC-III	8.0 [6.6–10.2]	7.5 [6.4–8.9]	0.0045	5.2	+7.9	+2.1	−3.2
ApoC-IV	0.09 [0.07–0.17]	0.04 [0.03–0.12]	0.0001	12.5	−14.5c	−21.3c	−18.9c
ApoD	3.8 [3.2–4.3]	3.1 [2.5–3.5]	0.0001	2.7	+8.8c	+2.1	−1.4
ApoE	6.4 [5.1–7.8]	6.3 [5.1–7.8]	0.4685	7.3	+58.7c	+47.3c	+43.2c
ApoF	0.38 [0.16–0.67]	0.44 [0.24–0.73]	0.1284	13.7	+5.4	+7.1	+3.5
ApoH	5.5 [4.7–6.3]	5.2 [4.6–5.9]	0.3832	4.8	+62.4c	+59.3c	+44.7c
ApoJ	11 [9–14]	11 [10–13]	0.4713	9.4	−4.3c	+2.1	−6.1c
ApoL1	1.0 [0.9–1.2]	1.3 [1.1–1.8]	0.0001	11.8	−6.3d	+1.2	+4.2
ApoM	2.5 [2.1–2.9]	2.4 [2.0–2.7]	0.1566	1.8	−5.4c	−2.3e	−1.8
Apo(a) (nM)	22 [12–63]	39 [16–77]	0.1085	3.8	+34.2c	+21.4c	+15.3c

Values are medians [25th to 75th percentiles]. Apolipoprotein concentrations are in milligrams per deciliter, unless otherwise specified. EDTA plasma samples were assayed five times. CVs were calculated over five experiments.

^aMann-Whitney test or unpaired t-test.

^bWilcoxon matched-pairs signed rank test or paired t-test.

^cP < 0.001.

^dP < 0.01.

^eP < 0.05.