Table 1.
List of lipidated proteins identified in human lens (data from Wang and Schey, (Wang and Schey, 2018a).
| Gene Name | Protein Description | Peptide | Sites | Modification |
|---|---|---|---|---|
| GNAI2 | Guanine nucleotide- binding protein G(i) subunit alpha-2 | G*C#TVSAEDKAAAER | G2, C3 | Myristoylation and palmitoylation |
| GNAI3 or GNAI1 | Guanine nucleotide- binding protein G(k) or G(i) subunit alpha | G * C#TLSA E D KAAV E R | G2, C3 | Myristoylation and palmitoylation |
| ERICH5 | Glutamate-rich protein 5 | G*C#SSSALNK | G2, C3 | Myristoylation and palmitoylation |
| FLOT1 | flotillin-1 | VFVLPC#IQQIQR | C34 | Palmitoylation |
| LIM2 | MP20 | RFGDWRFSWSYILGWVALLMTFFAGIF YMC#AYRMHECR | C159 | Palmitoylation |
| AQP5 | Aquaporin-5 | EVC#SVAFLK | C6 | Palmitoylation |
| GNAI2 | Guanine nucleotide- binding protein G(i) subunit alpha-2 | G*CTVSAEDKAAAER | G2 | Myristoylation |
| GNAI1 or GNAI3 | Guanine nucleotide- binding protein G(i) or G(k) subunit alpha | G*CTLSAEDKAAVER | G2 | Myristoylation |
| GNAI1 | Guanine nucleotide- binding protein G(i) subunit alpha-1 | G*CTLSAEDKAAVER | G2 | Myristoylation |
| ERICH5 | Glutamate-rich protein 5 | G*CSSSALNK | G2 | Myristoylation |
| BASP1 | Brain acid soluble protein 1 | G*GKLSKK | G2 | Myristoylation |
| MARC2 | Mitochondrial amidoxime reducing component 2 | G*AAGSSALAR | G2 | Myristoylation |
| TOMM4 0L | Mitochondrial import receptor subunit TOM40B | G*NTLGLAPMGALPR | G2 | Myristoylation |
| PSMC1 | 26S protease regulatory subunit 4 | G*QSQSGGHGPGGK | G2 | Myristoylation |
| PPM1A or PPM1B | Protein phosphatase 1A or 1B | G*AFLDKPK | G2 | Myristoylation |
| EEPD1 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | G*STLGCHR | G2 | Myristoylation |
| NDUFB7 | NADH dehydrogenase 1 beta subcomplex subunit 7 | G*AHLAR | G2 | Myristoylation |
| GORASP2 | Golgi reassembly-stacking protein 2 | G*SSQSVEIPGGGTEGYHVLR | G2 | Myristoylation |
| MGC127919 | Putative uncharacterized protein MGC127919 | G*SFVSQPLEPVK | G2 | Myristoylation |
| CHMP6 | Charged multivesicular body protein 6 | G*NLFGRK, G*NLFGR | G2 | Myristoylation |
| ARF4 | ADP-ribosylation factor 4 | G*LTISSLFSRLFGR | G2 | Myristoylation |
| ARF2 | ADP-ribosylation factor 2 | G*NVFEKLFKSLFGKK | G2 | Myristoylation |
| ARF1 | ADP-ribosylation factor 1 | G*NIFANLFKGLFGK | G2 | Myristoylation |
| CYB5R3 | NADH-cytochrome b5 reductase 3 | G*AQLSTLGHVVLSPVWFLYSLIMKLFQR | G2 | Myristoylation |
| MIP | Aquaporin 0 | M#WELR | M1 | N-fatty acylation |
| LSILK#GSRPSESNGQPEVTGEPVELK | K238 | N-fatty acylation | ||
| BFSP1 | Filensin | G*GQISK | G432 | Posttranslational N-myristoylation |
| RAB5A | Ras-related protein Rab-5A | GVDLTEPTQPTRSQC$C$SN | C212, C213 | Geranyl-geranyl |
| RAB1A | RAB1A, member RAS oncogene family | IQSTPVKQSGGGC$C$ | C204, C205 | Geranyl-geranyl |
| RAB14 | RAB14 protein | LTSEPQPQREGC$GC$ | C213, C215 | Geranyl-geranyl |
| RAB6A | Ras-related protein Rab-6A | LEKPQEQPVSEGGC$SC$ | C206, C208 | Geranyl-geranyl |
| RAB5C | Ras-related protein Rab-5C | GVDLQENNPASRSQC$C$SN | C213, C214 | Geranyl-geranyl |
| RAB2A | RAB2A, member RAS oncogene family | IGPQHAATNATHAGSQGGQQAGGGC$C$ | C188, C189 | Geranyl-geranyl |
*
Indicates sites of myristoylation
#
indicates sites of palmitoylation
$
indicates sites of geranylgeranylation