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. 2020 Jun 17;147(12):dev189886. doi: 10.1242/dev.189886

Fig. 6.

Fig. 6.

MEC-15 regulates synaptic functions of GABAergic motor neurons by antagonizing the activity of Hsp90 chaperones. (A) Synaptic puncta in the ventral neurite of GABAergic motor neurons labeled by juIs1[unc-25p::snb-1::GFP] in the wild-type animal, mec-15, mec-15; sti-1 and mec-15; pph-5 mutants. (B) Average fluorescent intensity (A.U., arbitrary units) of the SNB-1::GFP puncta in the indicated strains. (C) Average number of SNB-1::GFP puncta in 10 µm of the ventral neurite of GABAergic motor neurons in the indicated strains. (D) Percentage of adult animals paralyzed at the indicated time point after being exposed to 1 mM aldicarb. Animals were raised from embryos to young adults at either 20°C or 25°C before the test. Twenty animals and three replicates were used in each experiment. The experiment was repeated three times. Data are mean±s.d. The same mec-15 data were plotted twice in the two graphs for comparison with the double mutants (*P<0.05 and **P<0.01).