Fig. 3.

A summary of intracellular signaling pathways regulated by αvβ8 integrin. The cytoplasmic domain of β8 integrin can bind to various intracellular signaling effectors, including the non-receptor protein tyrosine phosphatase PTP-PEST, which subsequently regulates p130Cas activities in focal adhesions and VCP/p97 in the ubiquitin proteasome system. β8 integrin also binds directly to the Rho GTPase regulatory factor RhoGDI1, which controls the activation states of Rac1 and Cdc42 GTPase. Finally, the β8 integrin cytoplasmic domain can link to the actin cytoskeleton through interactions with Band 4.1 proteins.