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. 2020 Jun 24;13(6):dmm042549. doi: 10.1242/dmm.042549

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Loss of Msmo1 and Lss activity is associated with abnormal endochondral bone formation. (A-T) The hyomandibular (A,E,I,M,Q), ceratohyal (B,F,J,N,R) and hypural complex (C,D,G,H,K,L,O,P,S,T) were compared between wild type (A-D), kol^nu7 (E-H), kol^nu7/+:msmol^nu81/+ (I-L), Tg(fabp10a:msmo1:pA)^nu100;msmo1^nu81 (M-P) and Tg(fabp10:lss:pA)^nu101;lss^nu60 (Q-T). (E-T) The endochondral bones of the mutants are compressed and irregularly shaped with ectopic ossification and fusions throughout the growth plates, marked with arrows. Images represent disarticulated whole-mount adult skeletal preparations at ∼4 months of age. Scale bars: 100μm. Tg*, Tg(fabp10:msmo1:pA)^nu100; Tg**, Tg(fabp10:lss:pA)^nu101. wt n=4, kol^nu7 n=4, kol^nu7/+:msmol^nu81/+ n=4, Tg(fabp10a:msmo1:pA)^nu100;msmo1^nu81 n=4, Tg(fabp10:lss:pA)^nu101;lss^nu60 n=4.