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. 2020 Jun 17;147(12):dev187815. doi: 10.1242/dev.187815

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Chemokine levels are altered in the absence of ACKR2 and CCR1. Multiplex measurement of protein concentration of (A) inflammatory CC chemokines in whole mammary gland homogenates: (a) CCL2; (b) CCL3, two-tailed t-test, Ackr2^−/− (*P=0.0183) and Ccr1^−/− (**P=0.0082); (c) CCL5, two-tailed t-test, Ccr1^−/− (*P=0.0235); (d) CCL7, two-tailed t-test, Ackr2^−/− (*P=0.024); (e) CCL11, two-tailed t-test, Ackr2^−/− (**P=0.0014); (f) CCL12, two-tailed t-test, Ackr2^−/− (*P=0.0279); (g) CCL19, two-tailed t-test, Ackr2^−/− (*P=0.0216) and Ccr1^−/− (**P=0.0065); and (h) CCL22, two-tailed t-test, Ackr2^−/− (*P=0.0108) and Ccr1^−/− (*P=0.0184). (B) CXC chemokines: (a) CXCL1, two-tailed t-test, Ackr2^−/− (*P=0.0437) and Ccr1^−/− (**P=0.0023); (b) CXCL10, two-tailed t-test, Ackr2^−/− (**P=0.0020); (c) CXCL12, Mann–Whitney test, Ackr2^−/− (**P=0.0095), two-tailed t-test, Ccr1^−/− (**P=0.0086); wild type (CCR1) n=11, Ccr1^−/− n=11, wild type (ACKR2) n=6 and Ackr2^−/− n=4. Significantly different results are indicated. Data are mean±s.e.m.