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Proposed mechanism by which chemokine receptors CCR1 and ACKR2 coordinate mammary gland development. Oestrogen (blue lightning) increases CCR1 expression on macrophages (purple) during puberty, and stromal fibroblast (green)-expressed ACKR2 modulates levels of CCL7 (grey circles) to control the movement of CCR1+ macrophages to the ductal epithelium (orange). Schematic image was created with BioRender.
