Mean (SD) tricuspid regurgitation velocity by history of pulmonary embolism (PE) in the Walk-PHaSST (Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy) and University of Illinois at Chicago cohorts. In each cohort, P values were calculated from a multivariate regression analysis adjusted for age, sex, severe genotype, reticulocyte count, creatinine, and LV lateral E/A (Walk-PHaSST). TRV = tricuspid regurgitation velocity; UIC = University of Illinois at Chicago.