Table 1.
Clinical and laboratory findings by history of pulmonary embolism
| History of PE− | History of PE+ | |
|---|---|---|
| Walk-PHaSST | n = 637 | n = 31 |
| Age, yr | 36 (13.5) | 41 (12.5) |
| Female, n (%) | 342 (54) | 20 (65) |
| SS genotype, n (%) | 434 (76) | 18 (64) |
| Hemoglobin, mg/dl | 9.4 (1.9) | 9.8 (2.0) |
| Reticulocyte count, 109/L | 23.5 (12.9) | 19.8 (13.4) |
| White blood cell count, 109/L | 9.7 (3.8) | 9.7 (3.0) |
| Platelet count, 109/L | 354 (138) | 337 (95) |
| Creatinine, mg/dl | 0.87 (0.90) | 0.93 (0.54) |
| N-terminal-pro-BNP, pg/ml* | 65 (121) | 65 (145) |
| Left ventricular lateral E/A | 7.0 (2.8) | 6.5 (1.9) |
| TRV, m/s | 2.5 (0.40) | 2.8 (0.54) |
| UIC | n = 137 | n = 20 |
| Age, yr | 35 (13) | 34 (8.8) |
| Female, n (%) | 86 (64) | 14 (70) |
| SS genotype, n (%) | 115 (84) | 15 (75) |
| Hemoglobin, mg/dl | 9.1 (1.7) | 9.3 (2.0) |
| Reticulocyte count, 109/L | 32.0 (16.0) | 32.0 (14.0) |
| White blood cell count, 109/L | 9.8 (3.5) | 9.8 (2.6) |
| Platelet count, 109/L | 410 (150) | 410 (150) |
| Creatinine, mg/dl | 0.91 (0.68) | 0.90 (0.52) |
| N-terminal-pro-BNP, pg/ml* | 50 (16–169) | 87 (33–366) |
| Left ventricular lateral E/A | — | — |
| TRV, m/s | 2.4 (0.35) | 2.7 (0.62) |
Definition of abbreviations: BNP = brain natriuretic peptide; E/A = early to late diastolic transmitral flow velocity; PE = pulmonary embolism; PHaSST = Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy; SD = standard deviation; SS = hemoglobin SS; TRV = tricuspid regurgitation velocity; UIC = University of Illinois at Chicago.
Results are presented as mean (SD) unless otherwise specified.
*
Median (interquartile range).