Table 2.

Methylation Age Acceleration and Cognitive Function—ARIC Study (1990–1992)

	N	Model 1			Model 2			Model 3
		β	SE	p	β	SE	p	β	SE	p
Cognitive test
DWRT
Horvath age acceleration	2,155	−0.003	0.006	.654	−0.001	0.006	.868	−0.003	0.006	.672
Hannum age acceleration	2,155	−0.005	0.006	.457	−0.002	0.006	.705	−0.004	0.006	.530
DSST
Horvath age acceleration	2,135	0.043	0.042	.306	0.068	0.042	.106	0.061	0.042	.145
Hannum age acceleration	2,135	−0.053	0.042	.207	−0.024	0.042	.569	−0.014	0.044	.751
WFT
Horvath age acceleration	2,149	−0.025	0.044	.564	−0.007	0.044	.875	−0.013	0.045	.764
Hannum age acceleration	2,149	−0.140	0.044	.001	−0.119	0.044	.007	−0.104	0.046	.023

Note: Model 1: adjusted for age, sex, education; Model 2: covariates in Model 1 + APOE E4 (at least 1 E4 allele), smoking, body mass index, diabetes, hypertension, hypercholesterolemia; Model 3: covariates in Model 2 + white blood cell types; β = beta coefficient, DSST = Digit Symbol Substitution Test, DWRT = Delayed Word Recall Test, N = number, SE = Standard error, WFT = Word Fluency Test.