Table 3.
Methylation Age Acceleration and 6-Year Cognitive Change—ARIC Study (1990–1992)–(1996–1998)
| N | Model 1 | Model 2 | Model 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | p | β | SE | p | β | SE | p | ||
| Cognitive test | ||||||||||
| DWRT | ||||||||||
| Horvath age acceleration | 1,401 | 0.014 | 0.009 | .105 | 0.015 | 0.009 | .078 | 0.017 | 0.009 | .059 |
| Hannum age acceleration | 1,401 | 0.004 | 0.009 | .614 | 0.006 | 0.009 | .494 | 0.008 | 0.009 | .384 |
| DSST | ||||||||||
| Horvath age acceleration | 1,384 | 0.030 | 0.045 | .509 | 0.030 | 0.045 | .500 | 0.032 | 0.045 | .477 |
| Hannum age acceleration | 1,384 | 0.032 | 0.045 | .482 | 0.029 | 0.046 | .529 | 0.019 | 0.048 | .696 |
| WFT | ||||||||||
| Horvath age acceleration | 1,394 | −0.022 | 0.044 | .606 | −0.021 | 0.044 | .628 | −0.030 | 0.044 | .490 |
| Hannum age acceleration | 1,394 | 0.041 | 0.044 | .353 | 0.044 | 0.044 | .325 | 0.042 | 0.046 | .369 |
Note: Model 1: adjusted for age, sex, education; Model 2: covariates in Model 1 + APOE E4 (at least 1 E4 allele), smoking, body mass index, diabetes, hypertension, hypercholesterolemia; Model 3: covariates in Model 2 + white blood cell types; β = Beta coefficient, DSST = Digit Symbol Substitution Test, DWRT = Delayed Word Recall Test, N = number, SE = Standard error, WFT = Word Fluency Test.