Figure 1.

Old ghrelin knockout mice showed increased adiposity and reduced voluntary locomotor activity. Metabolic profiling of wild-type (WT) and Ghrl^–/– mice at 18 months of age. (A) Body weight and composition of the WT and Ghrl^–/– mice, n = 9–10. (B) Body composition of the WT and Ghrl^–/– mice, normalized to body weight, n = 9–10. (C) Daily food intake, n = 6. (D) Locomotor activity, n = 6. (E) Daily food intake in the presence of running wheels inside metabolic cages, n = 6. (F) Total distance run on the running wheels, n = 6. (G) Locomotor activity in the presence of running wheels, n = 6. Data are presented as mean ± SEM. *p < .05 versus WT mice, Student’s unpaired t test.