Figure 6.

METH induces serotonin release from whisker hair follicles. (a) Serotonin concentrations in the supernatant of Krebs solution in which hair follicles were incubated in the absence (control, open bar, n = 6) and presence of 100 µM METH (n = 6). In each experiment, five whisker hair follicles were pooled together and incubated at 24°C for a period of 2 h. (b) Serotonin concentrations in the supernatant of Krebs solution in which hair follicles were incubated with 100 µM METH for 5 min, 1, 2, 4, and 8 h (n = 6). In each experiment, five whisker hair follicles were pooled together and incubated at 24°C for the time indicated. Data represent the mean ± SEM. Sample sizes are numbers of experiments. *P < 0.05, **P < 0.01, ***P < 0.001, one-way analysis of variance with Bonferroni post hoc test. METH: methamphetamine.