Table 2.
Effect of CAR on Pancreatic Cancer in Different Subgroups.
| Subgroup | No. of studies | No. of patients | Effects model | HR (95%CI) | P | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I 2 (%) | P h | ||||||
| Overall survival | 11 | 2271 | Fixed | 1.84 (1.65-2.06) | <.001 | 49.2 | .033 |
| Ethnicity | |||||||
| Asian | 9 | 1863 | Random | 1.95 (1.59-2.39) | <.001 | 55.3 | .022 |
| Caucasian | 2 | 408 | Fixed | 1.65 (1.24-2.21) | .001 | 13.3 | .283 |
| Sample size | |||||||
| <200 | 6 | 733 | Fixed | 1.84 (1.50-2.25) | <.001 | 0 | .904 |
| ≥200 | 5 | 1538 | Random | 1.95 (1.44-2.65) | <.001 | 77.9 | .001 |
| Treatment | |||||||
| Surgery | 5 | 711 | Fixed | 1.79 (1.46-2.21) | <.001 | 0 | .646 |
| Chemotherapy | 3 | 970 | Random | 2.25 (1.40-3.62) | .001 | 84 | .002 |
| Chemotherapy + targeted therapy | 2 | 384 | Fixed | 1.48 (1.15-1.90) | .002 | 0 | .788 |
| Mixed | 1 | 206 | – | 2.02 (1.27-3.22) | .003 | – | – |
| Cutoff value of CAR | |||||||
| <0.20 | 6 | 1306 | Fixed | 1.79 (1.56-2.06) | <.001 | 0 | .736 |
| ≥0.20 | 5 | 965 | Random | 2.04 (1.38-3.03) | <.001 | 75.7 | .002 |
| Progression-free survival | 3 | 526 | Fixed | 1.53 (1.27-1.85) | <.001 | 0 | .892 |
| Disease-free survival | 2 | 231 | Fixed | 1.77 (1.30-2.41) | <.001 | 28.9 | .236 |
Abbreviations: CAR, C-reactive protein to albumin ratio; HR, hazard ratio.