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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Alcohol Clin Exp Res. 2020 May 18;44(6):1329–1336. doi: 10.1111/acer.14348

Fig. 5. Schematic representation: Chronic binge alcohol exposure during pregnancy alters mTOR system in rat fetal hippocampus.

Fig. 5.

The phosphorylation level of mTOR (P-mTOR) in the fetal hippocampus was decreased in the Alcohol group compared with controls. Alcohol exposure resulted in dysregulation of fetal hippocampal mTORC1 signaling, as evidenced by an increase in total 4E-BP1 expression. Phosphorylation levels of 4E-BP1 and p70 S6K were also increased following alcohol exposure. DEPTOR and RICTOR (not shown) expression levels in the fetal hippocampus were increased, however RAPTOR was not altered by chronic binge alcohol exposure.