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. 2020 Apr 14;30(4):746–765. doi: 10.1111/bpa.12831

Figure 5.

Figure 5

Effects of EC‐targeted overexpression of KLF11 on inflammatory mediators in mouse cortex after focal cerebral ischemia. EC‐KLF11 Tg and WT mice were subjected to sham operation or 1 h of MCAO followed by 1d or 3d of reperfusion. A–F. mRNA expression levels of different inflammatory markers were measured in the ipsilateral cortex by qPCR and normalized to cyclophilin. G and L. Protein levels of different inflammatory markers were analyzed by ELISA. EC‐targeted overexpression of KLF11 inhibited MCAO‐induced upregulation of TNFα, IL‐1β, MCP‐1, IL‐6, ICAM‐1 and P‐selectin expression. n = 6 mice per group. *P < 0.05 vs. WT + sham group, # P < 0.05 vs. WT + MCAO group.