Figure 7.

(A) Pathways enriched in lightcyan (Toll-like receptor–IL-17) and turquoise (unfolded protein response) weighted gene correlation network analysis modules of microRNA–mRNA expression. This figure summarizes the top five pathways enriched in the lightcyan and turquoise mRNA modules. (B) hsa-miR-223-3p gene regulation network. Upstream regulation enrichment analysis of the lightcyan and turquoise mRNA modules identified miR-223 as the only nely module microRNA with known or predicted regulatory effects in multiple genes present in the two mRNA modules. EIF2 = eukaryotic initiation factor 2; ERK/MAPK = extracellular-signal-regulated kinase/mitogen-activated protein kinase; NF-κB = nuclear factor–kappa B; PI3K/AKT = phosphatidylinositol 3-kinase/protein kinase B; TLR = Toll-like receptors; TNFR2 = tumor necrosis factor receptor 2.