Table 2.
9 PR proteins differentially released in STEMI vs. SAP.
| Gene name | Protein name | SAP log2 LFQ | STEMI log2 LFQ | Difference (mean log2 LFQ values) | Function |
|---|---|---|---|---|---|
| Proteins unique to STEMI | |||||
| FAH | Fumarylacetoacetase | NaN | 22.398 | NaN | Final enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia |
| Proteins unique to SAP | |||||
| CLEC3B | Tetranectin | 24.613 | NaN | NaN | Binds to Kringle 4 domain of plasminogen. May be involved in the packaging of molecules destined for exocytosis. |
| HSP90AA1 | Heat shock protein HSP 90-alpha | 24.132 | NaN | NaN | Molecular chaperone, involved in platelet activation. Extracellularly, mediates immune-regulatory & tissue remodeling. |
| Proteins with increased secretion in STEMI | |||||
| GPI | Glucose-6-phosphate isomerase | 24.76 | 26.013 | 1.171 | Glycolytic enzyme. Can also function extracellularly as a cytokine, an angiogenic, or neurotrophic factor. |
| PDIA3 | Protein disulfide-isomerase A3 | 26.026 | 26.671 | 1.093 | Protein folding, Molecular chaperone, secreted from platelets, Mediates platelet aggregation, haemostasis & thrombosis. |
| SAA1 | Serum amyloid A-1 protein | 22.977 | 23.784 | 2.692 | Major acute phase protein highly expressed in inflammation/tissue injury. Plays a role in HDL metabolism & cholesterol homeostasis. High levels associated with chronic inflammatory diseases including atherosclerosis. |
| SOD1 | Superoxide dismutase | 25.693 | 27.181 | 1.147 | One of two isozymes responsible for destroying free superoxide radicals in the body |
| Proteins with decreased secretion in STEMI | |||||
| F5 | Coagulation factor V | 28.229 | 27.63 | 1.679 | Critical cofactor for the prothrombinase activity of Factor Xa that results in the activation of prothrombin to thrombin |
| FN1 | Fibronectin | 29.416 | 28.669 | 2.768 | Component of subendothelial matrices and abundant in plasma. Important for stabilization of platelet aggregates after vascular injury. |
Nine proteins were found to be differentially released in the PR of STEMI vs. SAP. Associated gene name, protein name, the average log2 LFQ in both SAP and STEMI, the difference between the mean log2 LFQ values and the relevant known function of each protein are given.