Table 2.
Limit of detection of the existing biosensor platforms.
| breast cancer type/target | biosensor specifications | linear range (cells/ml) | detection limit (cells/ml) | reference |
|---|---|---|---|---|
| MCF-7 (MUC1) | porous GO/Au composites and PtFe alloy | 102–5 × 107 | 38 | [42] |
| MCF-7 (MUC1) | HRP/MUC1/aptamer1/Au electrode | 102–1 × 107 | 100 | [43] |
| MCF-7 (MUC1 and CEA) | MUC1/aptamer/MCF-7/anti-CEA-CdSNPs | 104–107 | 3.3 × 102 | [44] |
| MCF-7 (EpCAM) | anti-EpCAM/LC-SPDP/Au electrode | 105–107 | 1 × 105 | [45] |
| MCF-7 (HER-2) | anti-cerbB2/polypyrrole-NHS/GCE | 102–104 | 100 | [46] |
| SKBR-3 (HER-2) | S6 aptamer/AuNPs/ZnO/G/ITO electrode | 102–106 | 58 | [47] |
| SKBR-3 (HER-2) | NFG/AgNPs/PANI | 10–5 × 106 | 2 | [48] |
| SKBR-3 (HER-2) | hydrazine/AuNPs/aptamer | 50–2 × 104 | 26 | [49] |
| MB-231 and T47D (H2O2 traces in cells) | AuPtPd/rGO-modified GCE | 0.005 µM – 6.5 mM | 2 nM | [50] |
| T47D (EpCAM and HER-2) | anti-EpCAM/Au-Fe2O3/Bio.Anti-HER2/STE | 10–1 × 105 | 0.4 U ml−1 (LOD), 4 U ml−1 (LOQ) | this worka |
aLOD is the lowest concentration of the analyte detected in the sample but not quantitated under the stated conditions of the test. LOQ is the lowest concentration of the analyte determined with acceptable precision and accuracy under the stated conditions of test.