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TOE1 selectively rescues regular snRNAs from nuclear decay and promotes their maturation. (A) TOE1 opposes adenylation and processes 3′ tails of regular snRNAs, thus rescuing them from decay by the nuclear exosome and promoting their progression through snRNA biogenesis. (B) Variant U1 snRNAs are poorly processed by TOE1 and instead are substrates for degradation.
