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. 2020 Jul 1;34(13-14):950–964. doi: 10.1101/gad.338202.120

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© 2020 Gao et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 5. — Developmental stage-specific transcriptional regulatory networks (TRNs) and key regulators in the networks. (A) Schematic for the computational framework for constructing the TRNs. The framework consists of four key steps: (1) identifying stage-specific enhancers using epigenetic signatures, (2) linking enhancers to target promoters using the IM-PET algorithm, (3) linking TFs to target promoters using a probabilistic scoring function P_TG, and (4) identifying key TFs based on their regulatory potential on differentially expressed genes. (B) Key TFs predicted for four developmental transitions.